Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184110 | 0.96 | AKR1C2 (0.50) | AKR1C2AKR1C1POLBKMT2AMAPT | |
| SCHEMBL5155346 | 0.81 | AKR1C2 (0.44) | AKR1C2AKR1C1POLBMAPTKDM4E | |
| SCHEMBL4675271 | 0.78 | CYP2C8 (0.59) | AKR1C2AKR1C1POLBMAPTKDM4E | |
| SCHEMBL5156418 | 0.77 | AKR1C2 (0.44) | AKR1C2AKR1C1POLBMAPTHSD17B10 | |
| SCHEMBL4680433 | 0.73 | CYP2C8 (0.59) | AKR1C2AKR1C1POLBMAPTKDM4E | |
| SCHEMBL3422610 | 0.70 | MAPT (0.69) | POLBKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL18529832 | 0.70 | MAOB (0.42) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5188852 | 0.68 | MAPT (0.55) | AKR1C2AKR1C1POLBKMT2AMAPT | |
| SCHEMBL6585059 | 0.67 | MGLL (0.43) | MAPTKDM4E | |
| SCHEMBL6987433 | 0.67 | LTA4H (0.46) | KMT2AMAPTALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740558-A1 | BENZOXAZOCINES AND THEIR THERAPEUTIC USE AS MONOAMINE REUPTAKE INHIBITORS | Sosei R&D Ltd. (GB) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103019-A1 | BENZOXAZOCINES AND THEIR THERAPEUTIC USE AS MONOAMINE REUPTAKE INHIBITORS | SOSEI R&D LTD. (GB) | 2005-11-03 | — | — | WO | disclosed |