SCHEMBL5173183

SCHEMBL5173183

CCn1cc(Cc2ccccc2-c2cc(C(=O)NCc3ccccn3)c(OC)cc2C(=O)O)c2ccc(C(=N)N)cc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 6/20 0.49
ALDH1A1 P00352 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KDM4E B2RXH2 1/20 0.39
TLR9 Q9NR96 1/20 0.39
TLR8 Q9NR97 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
USP2 O75604 1/20 0.38
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
HPGD P15428 1/20 0.38
YWHAG P61981 1/20 0.38
F10 P00742 1/20 0.38
ROCK2 O75116 1/20 0.38
ROCK1 Q13464 1/20 0.38
PPARG P37231 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4815360 0.93 PDE10A (0.47) PDE10AALDH1A1SMN1; SMN2KDM4ETLR9
SCHEMBL4811010 0.85 KMT2A (0.44) PDE10AALDH1A1SMN1; SMN2KDM4ETLR9
SCHEMBL4815144 0.82 PPARG (0.41) PDE10AALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL4811052 0.80 CPT1A (0.39) F10PPARG
SCHEMBL4812552 0.79 PDE10A (0.42) PDE10AALDH1A1KDM4ETLR9TLR8
SCHEMBL4808748 0.78 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2KDM4EHPGDF10
SCHEMBL4811744 0.77 KMT2A (0.44) PDE10AALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL4811451 0.77 SLC22A12 (0.41) ALDH1A1KDM4EKMT2AMEN1HPGD
SCHEMBL4813419 0.77 F2 (0.43) ALDH1A1KDM4EHPGDF10ROCK2
SCHEMBL5258852 0.77 F10 (0.33) PDE10ASMN1; SMN2KMT2AF10ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1740538-A4 BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2007-12-19 EP claimed
EP-1740538-A2 BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS Bristol-Myers Squibb Company (US) 2007-01-10 EP claimed
WO-2005099709-A2 BICYCLIC HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-10-27 WO claimed