Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443908 | 0.79 | HTR2A (0.54) | NR3C1HTR2AHTR2CCYP3A4CYP2D6 | |
| SCHEMBL2447136 | 0.79 | KMO (0.45) | NR3C1HTR2AHTR2CKCNH2HTR1A | |
| SCHEMBL2443528 | 0.79 | NR3C1 (0.61) | NR3C1HTR2AHTR2CHTR1AADRA2A | |
| SCHEMBL2443310 | 0.77 | HTR2A (0.44) | NR3C1HTR2AHTR2CKCNH2SLC6A4 | |
| SCHEMBL2445235 | 0.77 | HTR2A (0.52) | NR3C1HTR2AHTR2CHTR1AADRA2A | |
| SCHEMBL4778532 | 0.77 | HTR2A (0.44) | NR3C1HTR2AHTR2CKCNH2SLC6A4 | |
| SCHEMBL2440808 | 0.73 | ALDH1A1 (0.51) | NR3C1HTR2AHTR2CKMT2AKMO | |
| SCHEMBL2451981 | 0.72 | MAPK10 (0.46) | NR3C1HTR2AHTR2CCYP3A4CYP2D6 | |
| SCHEMBL2445925 | 0.72 | HTR2A (0.60) | NR3C1HTR2AHTR2CHTR1AADRA2A | |
| SCHEMBL30259947 | 0.71 | RECQL (0.56) | HTR2AHTR2CHTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101759645-B | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2014-06-25 | — | — | CN | disclosed |
| CN-101759645-A | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2010-06-30 | — | — | CN | disclosed |
| CN-100579976-C | p38 inhibitors and methods of their use | ARRAY BIOPHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| EP-1606283-A4 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-05-23 | — | — | EP | disclosed |
| CN-1784396-A | p38 inhibitors and methods of their use | ARRAY BIOPHARMA INC (US) | 2006-06-07 | — | — | CN | disclosed |
| EP-1606283-A2 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004078116-A2 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2004-09-16 | — | — | WO | disclosed |