Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DDO | Q99489 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29657968 | 0.87 | AOC3 (0.52) | FLT3AOC3KDM4EMAPTDAO | |
| Benzene SCHEMBL11500406 | 0.85 | NPC1 (0.52) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL1002265 | 0.80 | AOC3 (0.45) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL1002262 | 0.80 | AOC3 (0.45) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL6654107 | 0.79 | AOC3 (0.52) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL6249932 | 0.78 | ALDH1A1 (0.46) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL5598773 | 0.75 | AOC3 (0.48) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL2775635 | 0.75 | FLT3 (0.48) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL11356701 | 0.74 | IDO1 (0.42) | FLT3AOC3KDM4EMAPTDAO | |
| SCHEMBL3900366 | 0.71 | AOC3 (0.37) | FLT3AOC3KDM4EMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202963-B1 | SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1144305-A4 | NOVEL sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2004-11-10 | — | — | EP | disclosed |
| US-6391908-B1 | ANTIINFLAMMATORY AGENTS; THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | disclosed |
| EP-1144305-A1 | NOVEL sPLA 2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037358-A1 | NOVEL sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |