SCHEMBL2775635

SCHEMBL2775635

O=Nc1cc2ccccc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 1/20 0.48
CYP2A6 P11509 1/20 0.48
AOC3 Q16853 2/20 0.48
KDM4E B2RXH2 3/20 0.47
DAO P14920 2/20 0.47
MAPT P10636 2/20 0.47
HPGD P15428 1/20 0.47
SRD5A2 P31213 1/20 0.47
HSD17B10 Q99714 1/20 0.47
BRD4 O60885 1/20 0.47
DDO Q99489 1/20 0.47
CA2 P00918 1/20 0.46
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
CHEK1 O14757 1/20 0.44
KDR P35968 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA3 P07451 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29657968 0.82 AOC3 (0.52) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL6654107 0.82 AOC3 (0.52) FLT3CYP2A6AOC3KDM4EDAO
Benzene SCHEMBL11500406 0.80 NPC1 (0.52) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL5598773 0.78 AOC3 (0.48) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL30012071 0.78 CHEK1 (0.44) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL28406859 0.78 FLT3 (0.44) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL11366274 0.78 CHEK1 (0.44) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL5173283 0.75 FLT3 (0.46) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL1002265 0.75 AOC3 (0.45) FLT3CYP2A6AOC3KDM4EDAO
SCHEMBL1002262 0.75 AOC3 (0.45) FLT3CYP2A6AOC3KDM4EDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118702611-A Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2024-09-27 CN claimed
CN-111662299-B Substituted indolocazazepine compound and preparation method and application thereof 中山大学 2022-07-26 CN claimed
US-20030119016-A1 Antisense oligonucleotides with increased RNase sensitivity THIRD WAVE TECHNOLOGIES, INC. 2003-06-26 US claimed
US-4314058-A Indolins styryl-like compounds MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1982-02-02 US claimed
CN-118702611-B Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2025-09-05 CN disclosed
CN-118702611-B Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2025-09-05 CN disclosed
CN-118702611-A Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2024-09-27 CN disclosed
CN-118702611-A Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2024-09-27 CN disclosed
CN-118702611-A Nitrosoindole alkaloid compound in purslane, and extraction and separation method and application thereof 辽宁中医药大学 2024-09-27 CN disclosed
US-11370757-B2 Photocleavable nitroindoline-based crosslinkers BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
US-7790877-B2 Antisense oligonucleotides with increased RNase sensitivity GEN-PROBE, INCORPORATED (US) 2010-09-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119016-A1 Antisense oligonucleotides with increased RNase sensitivity RNASE1, RNASEL, RNASEH1 FLT3 4426/4885CYP2A6 3822/4885AOC3 2175/4885
US-11370757-B2 Photocleavable nitroindoline-based crosslinkers OTUD7B, ALAD, NNMT FLT3 4579/4885CYP2A6 1050/4885AOC3 644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.