Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.73 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690270 | 1.00 | NAAA (0.73) | NAAAEPHX1ALDH1A1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28065417 | 0.98 | NAAA (0.71) | NAAAEPHX1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8140520 | 0.98 | NAAA (0.70) | NAAAEPHX1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1768014 | 0.94 | NAAA (0.65) | NAAAEPHX1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL103494 | 0.89 | — | — | |
| SCHEMBL2639022 | 0.88 | NAAA (0.86) | NAAAEPHX1SMN1; SMN2HSD17B10GAA | |
| SCHEMBL6359440 | 0.88 | NAAA (0.86) | NAAAEPHX1SMN1; SMN2HSD17B10GAA | |
| SCHEMBL3184451 | 0.87 | NAAA (0.66) | NAAAEPHX1SMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL4555028 | 0.86 | NAAA (0.96) | NAAAEPHX1GAAKEAP1NFE2L2 | |
| SCHEMBL2736687 | 0.86 | NAAA (0.83) | NAAAEPHX1KDM4ESMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | claimed |
| EP-1776349-B1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-06 | — | — | EP | claimed |
| WO-2008119719-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | claimed |
| US-20060079687-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-13 | — | — | US | claimed |
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2023-11-21 | — | — | US | disclosed |
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2023-11-21 | — | — | US | disclosed |
| WO-2023180189-A1 | MPRO TARGETING ANTIVIRAL COMPOUNDS | EXSCIENTIA AI LIMITED (GB) | 2023-09-28 | — | — | WO | disclosed |
| CN-110049983-B | Pharmaceutical compounds | 细胞中心有限公司 | 2022-06-14 | — | — | CN | disclosed |
| US-20210171508-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-06-10 | — | — | US | disclosed |
| US-20210147395-A1 | NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2021-05-20 | — | — | US | disclosed |
| CN-106107406-B | Methods of improving the stability of sweetness enhancers and compositions comprising stable sweetness enhancers | 弗门尼舍公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-107842706-B | running-in method for reducing friction coefficient between metal friction pairs | QILU UNIVERSITY OF TECHNOLOGY (CN) | 2019-12-10 | — | — | CN | disclosed |
| EP-1539774-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018489-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |
| US-5827863-A | Pyrazole derivatives as angiotensin II antagonists | J. URIACH & CIA, S.A. (ES) | 1998-10-27 | — | — | US | disclosed |
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| WO-1996004273-A1 | NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST | J. URIACH & CIA, S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147395-A1 | NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS | NEK4, NEK2, NEK1 | NAAA 2538/4885EPHX1 3411/4885ALDH1A1 4787/4885 |
| US-20060079687-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | BACE2, BACE1, APP | NAAA 189/4885EPHX1 1122/4885ALDH1A1 2650/4885 |
| US-20210171508-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | NAAA 4321/4885EPHX1 3770/4885ALDH1A1 3433/4885 |
| US-11820758-B2 | NEK6 kinase inhibitors useful for the treatment of solid tumors | NEK4, NEK2, NEK1 | NAAA 2538/4885EPHX1 3411/4885ALDH1A1 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.