Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.48 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269746 | 0.87 | HPGDS (0.61) | PDE4DKDM4ESMN1; SMN2HPGDSMAPK1 | |
| SCHEMBL2200266 | 0.83 | PDE4D (0.58) | PDE4DKDM4ESMN1; SMN2HPGDSMAPK1 | |
| SCHEMBL7460449 | 0.82 | PDE4D (0.52) | PDE4DKDM4ESMN1; SMN2HPGDSADORA3 | |
| SCHEMBL5271422 | 0.77 | KDM4E (0.64) | PDE4DKDM4ESMN1; SMN2HPGDSMAPK1 | |
| SCHEMBL1969117 | 0.74 | HPGDS (0.59) | KDM4ESMN1; SMN2HPGDSADORA3KMT2A | |
| SCHEMBL3263722 | 0.73 | HPGDS (0.57) | KDM4ESMN1; SMN2HPGDSMAPK1ADORA3 | |
| SCHEMBL7513038 | 0.73 | PDE4D (0.73) | PDE4DKDM4ESMN1; SMN2MAPK1KMT2A | |
| SCHEMBL10984267 | 0.73 | HSP90AA1 (0.62) | SMN1; SMN2HPGDSMAPK1KMT2AMEN1 | |
| SCHEMBL353564 | 0.72 | PDE4D (1.00) | PDE4DKDM4ESMN1; SMN2MAPK1KMT2A | |
| SCHEMBL17279852 | 0.72 | HPGDS (0.60) | KDM4ESMN1; SMN2HPGDSADORA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784400-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006023462-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-03-02 | — | — | WO | disclosed |