Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 8/20 | 0.53 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23629388 | 0.86 | TRAP1 (0.53) | TRAP1HSP90B1HSP90AA1ADORA2AALDH1A1 | |
| SCHEMBL8673254 | 0.84 | TRAP1 (0.52) | TRAP1HSP90B1HSP90AA1ADORA2ATLR7 | |
| SCHEMBL872294 | 0.82 | TRAP1 (0.55) | TRAP1HSP90B1HSP90AA1ADORA2ATLR7 | |
| SCHEMBL30012246 | 0.77 | KDM4E (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL23392966 | 0.77 | KDM4E (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4551932 | 0.75 | TRAP1 (0.54) | TRAP1HSP90B1HSP90AA1ADORA2A | |
| SCHEMBL3178085 | 0.75 | ADORA2A (0.58) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL22560008 | 0.74 | PNP (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL23991310 | 0.73 | TLR7 (0.46) | TRAP1HSP90B1HSP90AA1PDE4AADORA2A | |
| SCHEMBL2473169 | 0.71 | ADORA2A (0.53) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684236-B2 | Process of preparation of N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide | LONZA AG (CH) | 2007-12-26 | — | — | EP | disclosed |
| EP-0684236-B1 | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide and process for its production | LONZA AG (CH) | 1998-06-24 | — | — | EP | disclosed |
| US-5744601-A | N-(2-amino-4, 6-dichlopyrimidine-5-yl) formanide, and a process for its preparation | LONZA AG (CH) | 1998-04-28 | — | — | US | disclosed |
| US-5693800-A | N-(2-amino-4,6-dichloropyrimidine-5-yl) formamide and a process for its preparation | LONZA AG (CH) | 1997-12-02 | — | — | US | disclosed |
| US-5663340-A | N-(2-amino-4,6-dichloropyrimidine-5-yl)formamide, and a process for its preparation | LONZA AG (CH) | 1997-09-02 | — | — | US | disclosed |
| US-5583226-A | 4,6-dichloropyrimidine and related compounds | LONZA AG (CH) | 1996-12-10 | — | — | US | disclosed |
| EP-0684236-A2 | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide and process for its production | LONZA AG (CH) | 1995-11-29 | — | — | EP | disclosed |