Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176805 | 0.85 | FNTA (0.39) | MAPTNPSR1ALDH1A1FNTAFNTB | |
| SCHEMBL5127464 | 0.85 | MMP2 (0.37) | MAPTNPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL5176838 | 0.84 | CYP2D6 (0.43) | MAPTFNTAFNTBCA1CA2 | |
| SCHEMBL5177320 | 0.84 | FLT1 (0.40) | NPSR1ALDH1A1GAAFNTAFNTB | |
| SCHEMBL5175656 | 0.81 | CNR2 (0.44) | MAPTNPSR1ALDH1A1KDM4EFNTA | |
| SCHEMBL5176187 | 0.79 | FNTA (0.39) | MAPTNPSR1ALDH1A1GAAGLA | |
| SCHEMBL5175956 | 0.79 | FLT1 (0.40) | ALDH1A1GAAFNTAFNTBCA1 | |
| SCHEMBL5236529 | 0.78 | AVPR2 (0.40) | FNTAFNTB | |
| SCHEMBL5186094 | 0.78 | SLC6A9 (0.40) | MAPTALDH1A1FNTAFNTBPSEN1 | |
| SCHEMBL5186098 | 0.78 | SLC6A9 (0.40) | MAPTALDH1A1FNTAFNTBPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747195-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Incorporated (US) | 2007-01-31 | — | — | EP | claimed |
| WO-2005095334-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |