Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14123914 | 0.88 | SMN1; SMN2 (0.39) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL2687200 | 0.81 | SMN1; SMN2 (0.40) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL6845929 | 0.80 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL1453904 | 0.78 | L3MBTL1 (0.45) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL27944941 | 0.78 | MAPT (0.41) | ALDH1A1L3MBTL1GAAMAPK1LMNA | |
| SCHEMBL9601062 | 0.76 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL7975341 | 0.76 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL12112006 | 0.76 | TSHR (0.44) | ALDH1A1L3MBTL1KDM4EGAAMAPK1 | |
| SCHEMBL28808736 | 0.76 | MEN1 (0.38) | L3MBTL1GAASMN1; SMN2MAOAMAOB | |
| SCHEMBL10455674 | 0.76 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799638-A1 | PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006034966-A1 | PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-04-06 | — | — | WO | claimed |
| US-20230183164-A1 | Synthesis of Vinyl Cyclobutyl Intermediates | AMGEN INC. (US) | 2023-06-15 | — | — | US | disclosed |
| WO-2021226009-A1 | SYNTHESIS OF VINYL CYCLOBUTYL INTERMEDIATES | AMGEN INC. (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183164-A1 | Synthesis of Vinyl Cyclobutyl Intermediates | MCL1, BCL2A1, BAK1 | ALDH1A1 2468/4885L3MBTL1 1932/4885KDM4E 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.