Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2100439 | 1.00 | PTGDR2 (0.46) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2103458 | 0.97 | PTGDR2 (0.50) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2101693 | 0.97 | PTGDR2 (0.47) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2100243 | 0.87 | TSHR (0.49) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2103013 | 0.87 | TSHR (0.49) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2102473 | 0.84 | GCG (0.48) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL2099811 | 0.84 | TSHR (0.46) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2101408 | 0.84 | LMNA (0.53) | PTGDR2PTGDRTSHRHTR2AHTR2C | |
| SCHEMBL2100572 | 0.84 | ABCB11 (0.53) | PTGDR2NAAAHRH3SMN1; SMN2NPSR1 | |
| SCHEMBL3340724 | 0.84 | NAAA (0.51) | TSHRHTR2AHTR2BHPGDNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784388-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2007-05-16 | — | — | EP | claimed |
| WO-2006021759-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | WO | claimed |