Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672827 | 0.79 | IRAK4 (0.59) | CTNNB1SMN1; SMN2IRAK4HTTRAB9A | |
| SCHEMBL17045049 | 0.77 | CTNNB1 (0.56) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL5049439 | 0.76 | CTNNB1 (0.59) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL27511872 | 0.76 | KDM4E (0.46) | CTNNB1SMN1; SMN2IRAK4HTTRAB9A | |
| Methyl Alcohol SCHEMBL8782982 | 0.76 | CTNNB1 (0.93) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL8211650 | 0.76 | CTNNB1 (0.54) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL28876495 | 0.76 | CTNNB1 (1.00) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL27680126 | 0.76 | CTNNB1 (1.00) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL5724 | 0.76 | CTNNB1 (1.00) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 | |
| SCHEMBL27872615 | 0.75 | CTNNB1 (0.57) | CTNNB1SIRT2SIRT1BRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007518816-A | — | — | 2007-07-12 | — | — | JP | claimed |
| EP-1737414-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROPATIC PAIN | AMGEN INC. (US) | 2007-01-03 | — | — | EP | claimed |
| WO-2005072681-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROTIC PAIN. | AMGEN INC. (US) | 2005-08-11 | — | — | WO | claimed |