Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499160 | 0.94 | HSD11B1 (0.52) | HSD11B1TSHRFFAR4KMO | |
| SCHEMBL5203545 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL4504857 | 0.89 | KMT2A (0.46) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL4508310 | 0.89 | L3MBTL1 (0.51) | KDM4EHSD11B1GAAFFAR4KMO | |
| SCHEMBL5176608 | 0.88 | RXFP1 (0.48) | KDM4EALDH1A1HPGDHSD11B1FABP4 | |
| SCHEMBL4501662 | 0.87 | PKM (0.48) | HSD11B1PKM | |
| SCHEMBL24074863 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL4489474 | 0.85 | HSD17B2 (0.49) | HSD11B1TSHRGAAFFAR4 | |
| SCHEMBL4515721 | 0.85 | HSD11B1 (0.51) | HSD11B1TSHRFFAR4KMO | |
| SCHEMBL4504840 | 0.85 | BRD4 (0.45) | ALDH1A1HSD11B1FABP4FABP5RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789041-A2 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006010546-A2 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2006-02-02 | — | — | WO | disclosed |