Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175072 | 0.89 | CNR2 (0.42) | PPARGCNR2USP2MAPTNPSR1 | |
| SCHEMBL5113431 | 0.87 | MAPT (0.41) | PPARGCNR2USP2MAPTNPSR1 | |
| SCHEMBL5175956 | 0.87 | FLT1 (0.40) | KAT6AACP3SLC1A3SLC1A2FLT1 | |
| SCHEMBL5177184 | 0.86 | EPHX1 (0.39) | PPARGCNR2EPHX1CCR2 | |
| SCHEMBL5113412 | 0.86 | SCN8A (0.38) | PPARGCNR2USP2MAPTNPSR1 | |
| SCHEMBL5121770 | 0.85 | TRPM8 (0.39) | USP2MAPTNPSR1FLT1FLT4 | |
| SCHEMBL5186681 | 0.84 | S1PR3 (0.39) | MAPTNPSR1LMNASLC1A3SLC1A2 | |
| SCHEMBL5176226 | 0.84 | LMNA (0.40) | MAPTNPSR1LMNAFLT1FLT4 | |
| SCHEMBL5186687 | 0.84 | S1PR3 (0.39) | MAPTNPSR1LMNASLC1A3SLC1A2 | |
| SCHEMBL5176473 | 0.83 | MAPT (0.38) | PPARGMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747195-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Incorporated (US) | 2007-01-31 | — | — | EP | claimed |
| WO-2005095334-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |