Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | FEN1 | P39748 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501155 | 0.90 | BRD4 (0.47) | ABL1BRD4SLC22A12LMNAHTT | |
| SCHEMBL4506317 | 0.85 | HSD11B1 (0.50) | RXFP1ABL1BRD4SLC22A12LMNA | |
| SCHEMBL4493696 | 0.82 | KDM4E (0.47) | ABL1BRD4ALOX5APFEN1SLC22A12 | |
| SCHEMBL5176608 | 0.82 | RXFP1 (0.48) | RXFP1BRD4LMNAHTTPOLB | |
| SCHEMBL4502957 | 0.82 | PIK3C3 (0.48) | ABL1BRD4ALOX5APFEN1SLC22A12 | |
| SCHEMBL4495590 | 0.81 | LMNA (0.50) | RXFP1ABL1BRD4SLC22A12LMNA | |
| SCHEMBL4513639 | 0.81 | ABL1 (0.47) | ABL1BRD4SLC22A12LMNAHTT | |
| SCHEMBL5175959 | 0.80 | MCL1 (0.51) | ALOX5APFEN1LMNAHTTPOLB | |
| SCHEMBL4501015 | 0.80 | BRD4 (0.54) | BRD4SLC22A12HTTPOLBMEN1 | |
| SCHEMBL4500689 | 0.80 | PKM (0.48) | BRD4SLC22A12HTTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789041-A2 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006010546-A2 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2006-02-02 | — | — | WO | disclosed |