Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Thymine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.95 |
| ▸ | DPYD | Q12882 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HBB | P68871 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymine SCHEMBL17201833 | 0.97 | ATAD2 (1.00) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL750450 | 0.97 | ATAD2 (1.00) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL29669526 | 0.97 | — | — | |
| Thymine SCHEMBL15323914 | 0.97 | ATAD2 (1.00) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL5235 | 0.97 | — | — | |
| Thymine SCHEMBL935833 | 0.95 | ATAD2 (0.95) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL2724033 | 0.95 | ATAD2 (0.95) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL8649294 | 0.95 | ATAD2 (0.95) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL3500839 | 0.95 | ATAD2 (0.95) | ATAD2DPYDMAPTGAAALDH1A1 | |
| Thymine SCHEMBL4811815 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814867-A2 | ARYL PYRIMIDYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, THEIR USE AS ANTIMICROBIAL AGENTS | INSTITUT PASTEUR (FR) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006048336-A2 | ARYL PYRIMIDYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, THEIR USE AS ANTIMICROBIAL AGENTS | INSTITUT PASTEUR (FR) | 2006-05-11 | — | — | WO | disclosed |
| EP-0584185-A1 | TREATMENT OF FATIGUE SYNDROME WITH CHOLINESTERASE INHIBITORS | Snorrason, Ernir (IS) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992020327-A1 | TREATMENT OF FATIGUE SYNDROME WITH CHOLINESTERASE INHIBITORS | SNORRASON ERNIR (IS) | 1992-11-26 | — | — | WO | disclosed |