SCHEMBL517816

SCHEMBL517816

N#Cc1ccc(CNC=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.59
ADH1B P00325 1/20 0.55
ADH1C P00326 1/20 0.55
ADH1A P07327 1/20 0.55
ADH7 P40394 1/20 0.55
CYP19A1 P11511 1/20 0.51
CYP2A6 P11509 1/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA9 Q16790 1/20 0.46
SAE1 Q9UBE0 1/20 0.43
UBA2 Q9UBT2 1/20 0.43
EPHX2 P34913 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1983770 0.94 LOXL2 (0.53) LOXL2ADH1BADH1CADH1AADH7
SCHEMBL8763196 0.82 ADH1B (0.76) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL6562365 0.81 CA12 (0.51) LOXL2CYP19A1CYP2A6CA12CA1
SCHEMBL23879203 0.81 LOXL2 (0.71) LOXL2CYP19A1CYP2A6CA12CA1
SCHEMBL25629446 0.80 ADH1B (0.55) LOXL2ADH1BADH1CADH1AADH7
SCHEMBL24185722 0.80 LOXL2 (0.59) LOXL2CYP19A1CYP2A6CA12CA1
SCHEMBL12500340 0.78 TSHR (0.46) LOXL2CYP19A1CYP2A6CA12CA1
SCHEMBL12500205 0.78 ADH1B (0.53) ADH1BADH1CADH1AADH7CYP19A1
SCHEMBL4633427 0.77 ADH1B (0.52) LOXL2ADH1BADH1CADH1AADH7
SCHEMBL29912750 0.77 LOXL2 (0.65) LOXL2CYP19A1CYP2A6CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210130302-A1 Antiviral Pyrazolopyridinone Compounds NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC 2021-05-06 US claimed
EP-2661436-B1 NOVEL SULFAMIDE PIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF LEO PHARMA AS (DK) 2016-04-13 EP claimed
US-9233964-B2 Sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use therof LEO PHARMA A/S (DK) 2016-01-12 US claimed
US-20130345194-A1 SUBSTITUTED CYCLOPENTYL-AZINES AS CASR-ACTIVE COMPOUNDS LEO PHARMA A/S (DK) 2013-12-26 US claimed
EP-2661436-A1 NOVEL SULFAMIDE PIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF Leo Pharma A/S (DK) 2013-11-13 EP claimed
WO-2012093169-A1 NOVEL SULFAMIDE PIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF LEO PHARMA A/S (DK) 2012-07-12 WO claimed
US-20250353820-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS NOVARTIS AG (CH) 2025-11-20 US disclosed
US-12338220-B2 Antiviral pyrazolopiridinone compounds GILEAD SCIENCES, INC. (US) 2025-06-24 US disclosed
US-20230365511-A1 Antiviral Pyrazolopiridinone Compounds NOVARTIS AG (CH) 2023-11-16 US disclosed
EP-3781553-B1 HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2023-08-23 EP disclosed
US-11667613-B2 Antiviral pyrazolopyridinone compounds NOVARTIS AG (CH) 2023-06-06 US disclosed
EP-4034537-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS Novartis AG (CH) 2022-08-03 EP disclosed
CN-114667285-A Antiviral pyrazolopyridinone compounds 诺华股份有限公司 2022-06-24 CN disclosed
EP-0594540-B1 Antiretroviral acyl compounds CIBA GEIGY AG (CH) 1998-04-01 EP disclosed
WO-1998004542-A1 CHROMAN DERIVATIVES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-05 WO disclosed
US-5670497-A RETROVIRAL PROTEASE INHIBITORS CIBA-GEIGY CORPORATION (US) 1997-09-23 US disclosed
WO-1996039142-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PROTEINASE INHIBITOR AND A MONOGLYCERIDE F. HOFFMANN-LA ROCHE AG (CH) 1996-12-12 WO disclosed
EP-0708760-A1 CYCLIC HYDRAZINE COMPOUNDS Novartis AG (CH) 1996-05-01 EP disclosed
WO-1995002582-A1 CYCLIC HYDRAZINE COMPOUNDS CIBA-GEIGY AG (CH) 1995-01-26 WO disclosed
EP-0594540-A1 Antiretroviral acyl compounds CIBA-GEIGY AG (CH) 1994-04-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130345194-A1 SUBSTITUTED CYCLOPENTYL-AZINES AS CASR-ACTIVE COMPOUNDS JAK1, CNKSR1, TSHR LOXL2 1226/4885ADH1B 921/4885ADH1C 1123/4885
US-20250353820-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS ZC3HAV1, TYMP, ZC3HAV1L LOXL2 4761/4885ADH1B 2836/4885ADH1C 2698/4885
US-11667613-B2 Antiviral pyrazolopyridinone compounds ZC3HAV1, TYMP, ZC3HAV1L LOXL2 4761/4885ADH1B 2836/4885ADH1C 2698/4885
US-20230365511-A1 Antiviral Pyrazolopiridinone Compounds ZC3HAV1, ZC3HAV1L, RPL35 LOXL2 4676/4885ADH1B 2745/4885ADH1C 4024/4885
US-12338220-B2 Antiviral pyrazolopiridinone compounds ZC3HAV1, ZC3HAV1L, RPL35 LOXL2 4676/4885ADH1B 2745/4885ADH1C 4024/4885
US-20210130302-A1 Antiviral Pyrazolopyridinone Compounds ZC3HAV1, TYMP, ZC3HAV1L LOXL2 4761/4885ADH1B 2836/4885ADH1C 2698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.