Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263489 | 0.87 | NR1I2 (0.42) | MAOAMAOBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10413995 | 0.82 | MAOA (0.45) | MAOAMAOBHTTCES2CES1 | |
| SCHEMBL10414514 | 0.79 | HDAC3 (0.45) | MAOAMAOBHTTCES2CES1 | |
| SCHEMBL5749794 | 0.78 | ESR1 (0.58) | HTTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2297994 | 0.78 | GSK3B (0.54) | MAOAMAOBCES2CES1GSK3B | |
| SCHEMBL8410387 | 0.78 | SLC6A4 (0.36) | MAOAMAOBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5704306 | 0.78 | ALDH1A1 (0.44) | HTTCES2CES1GSK3BHDAC1 | |
| SCHEMBL2015853 | 0.76 | MAOA (0.55) | MAOAMAOBHTTCES2CES1 | |
| SCHEMBL10413993 | 0.76 | MAOA (0.55) | MAOAMAOBCES2CES1CA1 | |
| SCHEMBL11698205 | 0.76 | CYP19A1 (0.54) | MAOACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4956123-A | REACTING A STYRENE TYPE COMPOUND WITH A DIHALOACYL PEROXIDE TO MAKE A FLUOROALKYLAROMATIC ESTER | NIPPON OILS & FATS COMPANY, LTD. (JP) | 1990-09-11 | — | — | US | claimed |
| WO-2022169755-A1 | SULFONAMIDE SUBSTITUTED N-(1H-INDOL-7-YL) BENZENESULFONAMIDES AND USES THEREOF | TRIANA BIOMEDICINES, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| US-7259183-B2 | Indole, indazole and indoline derivatives as CETP inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | US | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
| US-4956123-A | REACTING A STYRENE TYPE COMPOUND WITH A DIHALOACYL PEROXIDE TO MAKE A FLUOROALKYLAROMATIC ESTER | NIPPON OILS & FATS COMPANY, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0189275-B1 | METHOD FOR MANUFACTURE OF FLUORINE-CONTAINING AROMATIC DERIVATIVES | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1989-10-18 | — | — | EP | disclosed |
| EP-0188905-B1 | FLAME RETARDANT MOLDED COMPOSITION WHICH INCORPORATES A POLY (STYRENE-CO-N-PHENYLMALEIMIDE-CO-DIBROMOSTYRENE) | ARCO CHEMICAL TECHNOLOGY, INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| US-4684692-A | Flame-retardant molded composition which incorporates a poly(styrene-CO-N-phenylmaleimide-CO-dibromostyrene) copolymer | ATLANTIC RICHFIELD COMPANY (US) | 1987-08-04 | — | — | US | disclosed |
| US-4668750-A | Flame-retardant molded composition which incorporates a poly(styrene-co-N-phenylmaleimide-co-dibromostyrene) copolymer | ATLANTIC RICHFIELD COMPANY (US) | 1987-05-26 | — | — | US | disclosed |
| US-4663386-A | Flame-retardant molded composition which incorporates a poly(styrene-co-N-phenylmaleimide-co-dibromostyrene)copolymer | ATLANTIC RICHFIELD COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| US-4625004-A | Flame-retardant molded composition which incorporates a poly (styrene-CO-N-phenylmaleimide-CO-dibromostyrene copolymer | ATLANTIC RICHFIELD COMPANY (US) | 1986-11-25 | — | — | US | disclosed |
| EP-0189275-A2 | Method for manufacture of fluorine-containing aromatic derivatives | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1986-07-30 | — | — | EP | disclosed |
| EP-0188905-A1 | Flame retardant molded composition which incorporates a poly (styrene-co-N-phenylmaleimide-co-dibromostyrene) | ARCO CHEMICAL TECHNOLOGY, INC. (US) | 1986-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | CETP, NAT1, MTTP | MAOA 227/4885MAOB 147/4885HTT 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.