SCHEMBL5178231

SCHEMBL5178231

COC(=O)c1c2c(c3cc(OC)ccc3c1C)OC(c1ccc(OC)cc1)(c1ccc(OC)cc1)C=C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.38
TDP1 Q9NUW8 1/20 0.38
KDM4E B2RXH2 8/20 0.38
HPGD P15428 6/20 0.38
ALDH1A1 P00352 6/20 0.38
HSD17B10 Q99714 4/20 0.38
HTT P42858 3/20 0.38
TSHR P16473 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
KMT2A Q03164 1/20 0.38
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
MAPT P10636 4/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
ALOX15 P16050 2/20 0.35
GAA P10253 2/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172997 0.96 PLA2G2A (0.38) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL5101722 0.94 KDM4E (0.36) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL6132018 0.91 L3MBTL1 (0.41) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL8978512 0.90 ATM (0.41) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL5645434 0.89 L3MBTL1 (0.38) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL6131983 0.88 L3MBTL1 (0.42) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL10102254 0.88 ATM (0.39) L3MBTL1TDP1HPGDALDH1A1HTT
SCHEMBL5647968 0.87 L3MBTL1 (0.33) L3MBTL1TDP1KDM4EHPGDALDH1A1
SCHEMBL17929226 0.86 ATM (0.38) L3MBTL1TDP1KDM4EALDH1A1HTT
SCHEMBL6650817 0.86 KMT2A (0.41) L3MBTL1KDM4EHPGDALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5458814-A Ophthalmic lenses TRANSITIONS OPTICAL, INC. (US) 1995-10-17 US claimed
EP-0890119-B1 PHOTOCHROMIC NAPHTHOPYRAN COMPOSITIONS OF NEUTRAL COLOR TRANSITIONS OPTICAL INC (US) 2007-06-20 EP disclosed
EP-0835870-B1 Photochromic substituted naphthopyrans PPG IND OHIO INC (US) 2004-03-03 EP disclosed
EP-0890119-A4 PHOTOCHROMIC NAPHTHOPYRAN COMPOSITIONS OF NEUTRAL COLOR TRANSITIONS OPTICAL INC (US) 2002-07-17 EP disclosed
EP-0890119-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOSITIONS OF NEUTRAL COLOR TRANSITIONS OPTICAL, INC. (US) 1999-01-13 EP disclosed
US-5753146-A CONTAINING ATLEAST TWO PHOTOCHROMATIC COMPOUNDS, SUCH AS 3(H)-NAPHTHO(2,1-B)PYRANS AND 2(H)-NAPHTHO(1,2-B)PYRANS, FREE OF AMINO SUBSTITUTED ARYL GROUPS ON CARBON ATOM ADJACENT TO THE OXYGEN ATOM OF PYRAN RING, EXPOSED TO ULTRAVIOLET RAYS TRANSITIONS OPTICAL, INC. (US) 1998-05-19 US disclosed
EP-0835870-A1 Photochromic substituted naphthopyrans PPG INDUSTRIES, INC. (US) 1998-04-15 EP disclosed
WO-1997037254-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOSITIONS OF NEUTRAL COLOR TRANSITIONS OPTICAL, INC. (US) 1997-10-09 WO disclosed
US-5656206-A OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM TRANSITIONS OPTICAL, INC. (US) 1997-08-12 US disclosed
US-5573712-A PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN TRANSITIONS OPTICAL, INC. (US) 1996-11-12 US disclosed
US-5458814-A Ophthalmic lenses TRANSITIONS OPTICAL, INC. (US) 1995-10-17 US disclosed