Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159327 | 0.88 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL8861452 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL159888 | 0.79 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL4120155 | 0.78 | MAPT (0.48) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL5166670 | 0.76 | HKDC1 (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL8390117 | 0.72 | INSR (0.48) | KDM4ESMN1; SMN2HKDC1MAPTMEN1 | |
| SCHEMBL8390120 | 0.72 | INSR (0.48) | KDM4ESMN1; SMN2HKDC1MAPTMEN1 | |
| SCHEMBL7781063 | 0.72 | MAPT (0.41) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL1656446 | 0.72 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2HPGDPKM | |
| SCHEMBL4149006 | 0.71 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2HKDC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1662318-B1 | 1,3-dihydro-1-oxo-2H-indene derivative | FUJIFILM CORP (JP) | 2007-06-06 | — | — | EP | disclosed |
| EP-1035435-B1 | Photosensitive composition and 1,3-dihydro-1-oxo-2H-indene derivative | FUJI PHOTO FILM CO LTD (JP) | 2006-08-09 | — | — | EP | disclosed |
| EP-1662318-A1 | 1,3-dihydro-1-oxo-2H-indene derivative | FUJI PHOTO FILM CO., LTD. (JP) | 2006-05-31 | — | — | EP | disclosed |
| US-6322950-B1 | Photosensitive composition and 1,3-dihydro-1-oxo-2H-indene derivative | FUJI PHOTO FILM CO., LTD. (JP) | 2001-11-27 | — | — | US | disclosed |
| EP-1035435-A2 | Photosensitive composition and 1,3-dihydro-1-oxo-2H-indene derivative | FUJI PHOTO FILM CO., LTD. (JP) | 2000-09-13 | — | — | EP | disclosed |