Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.50 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.50 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624933 | 0.86 | DRD2 (0.56) | LDHAALDH1A1HTTDRD3KMT2A | |
| SCHEMBL5244436 | 0.86 | LDHA (0.47) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5244142 | 0.86 | LDHA (0.51) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5244348 | 0.86 | LDHA (0.49) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5240305 | 0.85 | LDHA (0.51) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5239926 | 0.84 | LDHA (0.50) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5241918 | 0.84 | LDHA (0.50) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5243800 | 0.83 | LDHA (0.49) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5240739 | 0.83 | LDHA (0.49) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5242749 | 0.83 | LDHA (0.49) | LDHAPRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | claimed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | claimed |
| EP-1729762-A4 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1729762-A2 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORPORATION (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094305-A2 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORPORATION (US) | 2005-10-13 | — | — | WO | disclosed |
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |