Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 4/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434352 | 0.74 | TSPO (0.52) | TSPOAOC3HSD17B2TAS2R14ALDH1A1 | |
| SCHEMBL5183298 | 0.74 | KDM4E (0.52) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5184688 | 0.72 | KDM4E (0.47) | ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL25173275 | 0.69 | KDM4E (0.60) | ROCK2CYP2C9ROCK1ACHEALDH1A1 | |
| SCHEMBL30393323 | 0.69 | KDM4E (0.60) | ROCK2CYP2C9ROCK1ACHEALDH1A1 | |
| SCHEMBL11364192 | 0.69 | AOC3 (0.76) | AOC3 | |
| SCHEMBL29565507 | 0.67 | RIPK1 (0.65) | AOC3ALDH1A1HTTALOX5RIPK1 | |
| SCHEMBL17278345 | 0.67 | RIPK1 (0.61) | AOC3ALDH1A1HTTALOX5RIPK1 | |
| SCHEMBL24723324 | 0.66 | KDM4E (0.65) | CYP2C9ACHEMAPK1 | |
| SCHEMBL25169836 | 0.66 | CDK4 (0.61) | ALDH1A1HTTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006030032-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-23 | — | — | WO | disclosed |