Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525526 | 0.82 | MAPK1 (0.62) | L3MBTL1GAANPC1RAB9AMAPT | |
| SCHEMBL525271 | 0.81 | KDM1A (0.54) | L3MBTL1KDM1AGAAPOLBNPC1 | |
| SCHEMBL2285389 | 0.80 | AMY1A (0.60) | L3MBTL1KDM1AGAAPOLBNPC1 | |
| SCHEMBL525812 | 0.76 | KDM1A (0.56) | L3MBTL1KDM1AGAAPOLBNPC1 | |
| SCHEMBL525682 | 0.76 | KDM1A (0.76) | KDM1AGAANPC1RAB9AAMY1A | |
| SCHEMBL11886334 | 0.76 | CSNK2A1 (0.52) | L3MBTL1KDM1AGAAPOLBNPC1 | |
| SCHEMBL5200233 | 0.76 | MAPT (0.68) | L3MBTL1KDM1AGAANPC1RAB9A | |
| SCHEMBL19667960 | 0.76 | L3MBTL1 (0.51) | L3MBTL1KDM1AGAAPOLBAMY1A | |
| SCHEMBL4927053 | 0.76 | L3MBTL1 (0.55) | L3MBTL1KDM1AGAAPOLBNPC1 | |
| SCHEMBL4919827 | 0.76 | KDM1A (0.76) | L3MBTL1KDM1AGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |