Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | DRD2 | P14416 | 7/20 | 0.50 |
| ▸ | HTR7 | P34969 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ILK | Q13418 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185914 | 0.91 | HTR1A (0.56) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| SCHEMBL5185915 | 0.89 | SLC6A4 (0.64) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| SCHEMBL7523236 | 0.89 | SLC27A1 (0.66) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL7522315 | 0.88 | SLC6A4 (0.63) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL7523122 | 0.88 | SLC27A1 (0.64) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| SCHEMBL7518692 | 0.85 | SLC27A1 (0.48) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| SCHEMBL5185969 | 0.84 | DRD2 (0.59) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| SCHEMBL5185901 | 0.84 | DRD2 (0.50) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| Fumaric Acid SCHEMBL7529655 | 0.83 | DRD2 (0.56) | SLC27A1HTR1AHTR2ASLC6A4DRD2 | |
| Fumaric Acid SCHEMBL7529648 | 0.83 | DRD2 (0.56) | SLC27A1HTR1AHTR2ASLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325917-B1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-03 | — | — | EP | claimed |
| EP-0912533-B1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2004-09-29 | — | — | EP | claimed |
| EP-1325917-A1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-09 | — | — | EP | claimed |
| EP-0912533-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-05-06 | — | — | EP | claimed |
| WO-1997043271-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-20 | — | — | WO | claimed |
| EP-1325917-B1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-03 | — | — | EP | disclosed |
| EP-0912533-B1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2004-09-29 | — | — | EP | disclosed |
| EP-1325917-A1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-09 | — | — | EP | disclosed |
| US-6224849-B1 | Alkylaminobenzothiazole and-benzoxazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-05-01 | — | — | US | disclosed |
| US-6103725-A | HIGH AFFINITY TO THE DOPAMINE D4 RECEPTOR; ANTAGONISTS; ANTIPSYCHOTIC AGENTS, E.G. SCHIZOPHRENIA, WITH REDUCED SIDE-EFFECTS; ANTIPSYCHOTIC AGENTS; ANXIOLYTIC AND ANTIEMETIC AGENTS; MOTORIC FUNCTIONS, ADDICTION, SLEEP, FEEDING | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-15 | — | — | US | disclosed |
| EP-0912533-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043271-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-20 | — | — | WO | disclosed |