Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187236 | 0.87 | LMNA (0.44) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5188030 | 0.82 | KMT2A (0.51) | SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6273588 | 0.77 | LMNA (0.41) | HPGD | |
| SCHEMBL31164812 | 0.77 | NPC1 (0.61) | NPC1RAB9ACA12CA9CHRNB2 | |
| SCHEMBL2095210 | 0.76 | NPC1 (0.67) | NPC1RAB9ACA12CA9CHRNB2 | |
| SCHEMBL29020266 | 0.76 | TSHR (0.51) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL5656197 | 0.75 | APOBEC3A (0.55) | NPC1RAB9ACA12CA9APOBEC3A | |
| SCHEMBL3882545 | 0.72 | RAB9A (0.39) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2095207 | 0.72 | NPC1 (0.59) | NPC1RAB9ACA12CA9CHRNB2 | |
| SCHEMBL6277045 | 0.71 | NPC1 (0.62) | NPC1RAB9ACA12CA9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
| EP-1581490-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | Grünenthal GmbH (DE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058707-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | Grünenthal GmbH (DE) | 2004-07-15 | — | — | WO | disclosed |