Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 4/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184788 | 0.94 | TRPM8 (0.58) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL5187485 | 0.89 | LPAR1 (0.48) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL14078347 | 0.87 | TRPM8 (0.69) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL5110016 | 0.82 | MTNR1A (0.58) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| Trifluoroacetic Acid SCHEMBL5106762 | 0.82 | TRPM8 (0.62) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL14078310 | 0.82 | TRPM8 (0.62) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL5107779 | 0.82 | TRPM8 (0.62) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL5122218 | 0.81 | TRPM8 (0.61) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| SCHEMBL14078352 | 0.81 | TRPM8 (0.64) | MEN1KMT2ATRPM8KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL5114925 | 0.80 | TRPM8 (0.62) | MEN1KMT2ATRPM8KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802600-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONITS FOR THE TREATMENT OF UROLOGICAL DISORDERS | Bayer HealthCare AG (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040136-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONISTS FOR THE TREATMENT OF UROLOGICAL DISORDER | BAYER HEALTHCARE AG (DE) | 2006-04-20 | — | — | WO | disclosed |