SCHEMBL5186990

SCHEMBL5186990

CC(C)Cc1c(N)c(CC(C)C)c(CC(C)C)c(N)c1CC(C)C

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22351911 0.81 NOS3 (0.32) NOS3NOS1NOS2
SCHEMBL8165011 0.79 NOS3 (0.31) NOS3NOS1NOS2
SCHEMBL20223449 0.75
SCHEMBL12848645 0.73 TLR8 (0.30)
SCHEMBL1498799 0.73 NOS3 (0.39) NOS3NOS1NOS2
SCHEMBL1498797 0.69 GABRA1 (0.38) NOS3NOS1NOS2
SCHEMBL21685308 0.69 DPP4 (0.37) NOS3NOS1NOS2
SCHEMBL9286489 0.68 NOS3 (0.39) ALDH1A1MAPK1NOS3NOS1NOS2
SCHEMBL22342929 0.67 DPP4 (0.36) NOS3NOS1NOS2
SCHEMBL19233200 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1004925-B1 Polyimide photo alignment film from 3,3',4,4'-benzophenone tetracarboxylic dianhydride and ortho-substituted aromatic diamines for liquid crystal displays DU PONT (US) 2007-07-11 EP disclosed
EP-0768559-B1 Active-matrix liquid crystal displays with polyimide alignment films from 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane, dianhydride and ortho-substituted aromatic diamines DU PONT (US) 2003-08-13 EP disclosed
US-6348245-B1 POLYIMIDE ALIGNMENT LAYER HAVING VERY HIGH VOLTAGE HOLDING RATIO, STABLE LOW TILT ANGLE, LOW RESIDUAL DIRECT CURRENT VOLTAGE E. I. DU PONT DE NEMOURS AND COMPANY 2002-02-19 US disclosed
US-6139926-A Polyimide photo alignment film from 3,3,4,4-benzophenone tetracarboxylic dianhydride and ortho-substituted aromatic diamines for liquid crystal displays E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-10-31 US disclosed
EP-1004925-A2 Polyimide photo alignment film from 3, 3'4,4'-Benzophenone tetracarboxylic dianhydride and ortho-substituted aromatic diamines for liquid crystal displays E. I. du Pont de Nemours and Company (US) 2000-05-31 EP disclosed
US-5759442-A Polyimide alignment film from 2,2-BIS (3,4-dicarboxyphenyl)--hexafluoropropane dianhydride and ortho-substituted aromatic diamines for active matrix liquid crystal displays E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-06-02 US disclosed
EP-0768559-A1 Polyimide alignment film from 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane, dianhydride and ortho-substituted aromatic diamines for active matrix liquid crystal displays E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-04-16 EP disclosed
EP-0365855-A1 Orientation layer composition for liquid crystal display devices Hitachi Chemical Co., Ltd. (JP) 1990-05-02 EP disclosed