Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.78 |
| ▸ | HTT | P42858 | 5/20 | 0.78 |
| ▸ | NPC1 | O15118 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746726 | 0.88 | MEN1 (1.00) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL7896679 | 0.84 | RAB9A (0.59) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL7254811 | 0.83 | RAB9A (0.71) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL1019968 | 0.82 | EPHX2 (0.74) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL13235126 | 0.82 | HTT (0.81) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL8497569 | 0.82 | POLB (0.66) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL6799221 | 0.81 | RAB9A (0.73) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL1514777 | 0.81 | NPC1 (0.73) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL7545396 | 0.81 | MEN1 (0.62) | RAB9AHTTNPC1MEN1KMT2A | |
| SCHEMBL4745756 | 0.80 | EPHX2 (0.71) | RAB9ANPC1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | disclosed |