Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | NPC1 | O15118 | 7/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | DDX3X | O00571 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.60 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812756 | 0.88 | DDX3X (0.80) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL3460448 | 0.86 | RAB9A (0.71) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL5852186 | 0.85 | DDX3X (0.70) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL34468112 | 0.83 | DDX3X (0.77) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL5681280 | 0.83 | ITGB1 (0.54) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL6373673 | 0.83 | ITGB1 (0.64) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL5865365 | 0.83 | ITGB1 (0.54) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL1019968 | 0.82 | EPHX2 (0.74) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL1275926 | 0.82 | RAB9A (0.75) | RAB9ANPC1MAPTPOLBKMT2A | |
| SCHEMBL8497569 | 0.82 | POLB (0.66) | RAB9ANPC1MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| US-6750344-B1 | MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-6316626-B1 | Amine compounds and combinatorial libraries comprising same | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |