Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595039 | 0.84 | CXCR1 (0.59) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL27953196 | 0.82 | CFD (0.67) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL5188558 | 0.81 | RAB9A (0.78) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL17744942 | 0.79 | HDAC6 (0.68) | LMNARAB9AHDAC6HDAC2HDAC8 | |
| SCHEMBL8746726 | 0.79 | MEN1 (1.00) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL12336152 | 0.78 | NAMPT (0.77) | MEN1KMT2AHTTNAMPTHDAC1 | |
| SCHEMBL11900090 | 0.77 | HDAC6 (0.85) | LMNARAB9AHDAC6HDAC2HDAC8 | |
| SCHEMBL16286257 | 0.76 | KMT2A (0.66) | MEN1KMT2ALMNAHTTNAMPT | |
| SCHEMBL8042301 | 0.76 | HDAC6 (0.77) | KMT2ALMNARAB9AHDAC6HDAC2 | |
| SCHEMBL18601428 | 0.75 | KMT2A (0.68) | MEN1KMT2ALMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |