Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5188224 | 0.87 | KDM4E (0.43) | KDM4EPOLBSCN1ASCN2ASCN3A | |
| SCHEMBL5187264 | 0.85 | BCHE (0.46) | KDM4EMEN1KMT2AALDH1A1CPT2 | |
| SCHEMBL3761870 | 0.84 | KDM4E (0.47) | KDM4EPOLBSCN1ASCN2ASCN3A | |
| SCHEMBL5187738 | 0.82 | ACHE (0.47) | KDM4EPOLBALDH1A1LMNABCHE | |
| SCHEMBL4657753 | 0.79 | ALDH1A1 (0.48) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL3756217 | 0.76 | KDM4E (0.45) | KDM4EPOLBSCN1ASCN2ASCN3A | |
| SCHEMBL3761869 | 0.71 | GAA (0.50) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL18779478 | 0.69 | ALDH1A1 (0.71) | KDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL6694425 | 0.69 | ALDH1A1 (0.71) | KDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL30596558 | 0.69 | ALDH1A1 (0.71) | KDM4EPOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751101-B1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | claimed |
| EP-1751101-B1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | disclosed |
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |