Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19739343 | 0.92 | HPSE (0.47) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL30045370 | 0.89 | MAPT (0.48) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL30045333 | 0.86 | TP53 (0.47) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL5189432 | 0.85 | DGAT1 (0.59) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL2980576 | 0.84 | BTK (0.42) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL5189138 | 0.83 | SMN1; SMN2 (0.53) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL5207426 | 0.83 | KDM4E (0.53) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL19739073 | 0.80 | MAPT (0.40) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL5188247 | 0.80 | HPSE (0.58) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL3109194 | 0.80 | TUBB4A (0.47) | MMP2MMP9MMP8MMP13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831218-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066914-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |