Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5189432 | 0.88 | DGAT1 (0.59) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL5190823 | 0.85 | KDM4E (0.53) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL5189138 | 0.85 | SMN1; SMN2 (0.53) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL2977835 | 0.84 | KDM4E (0.42) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL5189308 | 0.83 | MMP2 (0.48) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL5272080 | 0.80 | KCNQ2 (0.60) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL5188247 | 0.80 | HPSE (0.58) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL5202947 | 0.79 | MEN1 (0.50) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL2245457 | 0.77 | MMP2 (0.58) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL4480173 | 0.77 | DGAT1 (0.60) | KDM4ESMN1; SMN2MAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831218-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066914-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |