Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032534 | 0.73 | HPGD (0.53) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1032502 | 0.70 | TNKS2 (0.68) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9070566 | 0.67 | TNKS (0.63) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14721781 | 0.65 | HPGD (0.54) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10181290 | 0.65 | HSD11B1 (0.59) | KMT2A | |
| SCHEMBL1035972 | 0.63 | HPGD (0.71) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1036534 | 0.63 | HPGD (0.71) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4148644 | 0.63 | KDM4E (0.66) | HPGDTSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8600785 | 0.63 | HTR6 (0.47) | KMT2A | |
| SCHEMBL12050029 | 0.63 | POLB (0.52) | HPGDTSHRKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856061-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |