Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195267 | 0.83 | ALDH1A1 (0.41) | TSHRKDM4ELMNAMAPK1ALDH1A1 | |
| SCHEMBL5193895 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1 | |
| SCHEMBL5195658 | 0.80 | ALDH1A1 (0.44) | KDM4EHTTMAPK1ALDH1A1 | |
| SCHEMBL5208487 | 0.78 | NOS2 (0.39) | NOS2ALDH1A1GAA | |
| SCHEMBL5195794 | 0.77 | ALDH1A1 (0.44) | TSHRLMNAALDH1A1POLBGAA | |
| SCHEMBL5190961 | 0.74 | TSHR (0.51) | TSHRUSP2KDM4EHTTLMNA | |
| SCHEMBL5190316 | 0.73 | NOS2 (0.68) | NOS2 | |
| SCHEMBL5190775 | 0.73 | MAPT (0.49) | TSHRHTTLMNAMAPK1ALDH1A1 | |
| SCHEMBL5194006 | 0.68 | CYP19A1 (0.47) | NOS2KDM4EHTTALDH1A1TDP1 | |
| SCHEMBL179083 | 0.68 | LMNA (0.64) | TSHRUSP2KDM4EHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |