Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10674002 | 0.84 | LTA4H (0.54) | LTA4HKDM4ESIGMAR1PKM | |
| SCHEMBL5191015 | 0.81 | SMN1; SMN2 (0.56) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL28046102 | 0.79 | KDM4E (0.47) | KDM4ESIGMAR1POLBPKMSLC18A3 | |
| SCHEMBL7063658 | 0.79 | NPY2R (0.41) | KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4287551 | 0.78 | LTA4H (0.63) | LTA4HSIGMAR1SMN1; SMN2DRD4 | |
| SCHEMBL12520647 | 0.78 | LTA4H (0.63) | LTA4HSIGMAR1SMN1; SMN2DRD4 | |
| SCHEMBL5192443 | 0.77 | ALDH1A1 (0.48) | KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL6076846 | 0.76 | MLNR (0.49) | LTA4HMLNR | |
| SCHEMBL5193199 | 0.76 | MAPT (0.55) | SMN1; SMN2 | |
| SCHEMBL691646 | 0.76 | LTA4H (0.54) | LTA4HSIGMAR1PKMDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |