Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP3 | P08254 | 6/20 | 0.45 |
| ▸ | MMP7 | P09237 | 6/20 | 0.45 |
| ▸ | MMP2 | P08253 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | NPR3 | P17342 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194761 | 0.91 | PYGL (0.39) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5423348 | 0.88 | MMP13 (0.56) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5197189 | 0.87 | MMP13 (0.38) | MMP13AAK1ALDH1A1NPR3 | |
| SCHEMBL5194286 | 0.87 | MMP13 (0.54) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5192366 | 0.84 | KDM4E (0.48) | MMP13AAK1ALDH1A1CTSLCTSK | |
| SCHEMBL5194502 | 0.81 | KMT2A (0.39) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5431737 | 0.78 | MAPK1 (0.41) | MMP1ALDH1A1SMN1; SMN2CACNA1BNPC1 | |
| SCHEMBL5192018 | 0.77 | MMP13 (0.41) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5192008 | 0.77 | MMP13 (0.41) | MMP13MMP1MMP3MMP7MMP2 | |
| SCHEMBL5422392 | 0.76 | MAPK1 (0.41) | MMP1ALDH1A1SMN1; SMN2CACNA1BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |