Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.54 |
| ▸ | MMP2 | P08253 | 11/20 | 0.54 |
| ▸ | MMP3 | P08254 | 11/20 | 0.54 |
| ▸ | MMP1 | P03956 | 10/20 | 0.54 |
| ▸ | MMP7 | P09237 | 7/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | PYGL | P06737 | 6/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423348 | 0.99 | MMP13 (0.56) | MMP13MMP2MMP3MMP1MMP7 | |
| SCHEMBL5192203 | 0.87 | MMP13 (0.46) | MMP13MMP2MMP3MMP1MMP7 | |
| SCHEMBL5192086 | 0.86 | PYGL (0.49) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5194927 | 0.86 | PYGL (0.49) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5195559 | 0.85 | PYGL (0.45) | MMP13MMP2MMP3MMP1MMP7 | |
| SCHEMBL5194492 | 0.83 | PYGL (0.48) | PYGLCYP2C9 | |
| SCHEMBL5192583 | 0.83 | MMP13 (0.53) | MMP13MMP2MMP3MMP1MMP7 | |
| SCHEMBL5196528 | 0.83 | MMP13 (0.55) | MMP13MMP2MMP3MMP1MMP7 | |
| SCHEMBL5427731 | 0.81 | PYGL (0.48) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5191862 | 0.80 | PYGL (0.55) | PYGLCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |