Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191103 | 0.87 | RAB9A (0.51) | RAB9ASMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL5195550 | 0.86 | RAB9A (0.51) | RAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL5779414 | 0.85 | SRC (0.50) | RAB9ASMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL5195710 | 0.84 | ALDH1A1 (0.58) | RAB9ASMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL5193944 | 0.80 | LMNA (0.48) | RAB9ASMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL5191447 | 0.78 | HPGD (0.57) | RAB9ASMN1; SMN2POLBALDH1A1KDM4E | |
| SCHEMBL5190932 | 0.78 | EPHX2 (0.52) | RAB9ASMN1; SMN2ALDH1A1NPC1KMT2A | |
| SCHEMBL5193954 | 0.75 | EPHX2 (0.50) | RAB9APOLBLMNANPC1KMT2A | |
| SCHEMBL22738143 | 0.74 | KDM4E (0.64) | SMN1; SMN2POLBALDH1A1KDM4ELMNA | |
| SCHEMBL21206860 | 0.74 | HTR2C (0.70) | RAB9ASMN1; SMN2POLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |