Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 4/20 | 0.59 |
| ▸ | CA2 | P00918 | 4/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13771219 | 0.92 | TAS1R3 (0.55) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL10980522 | 0.86 | TAS1R3 (0.59) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL5637591 | 0.84 | CA2 (0.58) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL9829827 | 0.84 | CA2 (0.58) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL8330051 | 0.83 | CA1 (0.66) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL7410707 | 0.81 | NPSR1 (0.71) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL5838728 | 0.81 | NPSR1 (0.71) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL9828979 | 0.80 | NPSR1 (0.57) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL5424180 | 0.80 | TAS1R3 (0.61) | TAS1R3TAS1R1CA1CA2PLK1 | |
| SCHEMBL9829566 | 0.80 | CA2 (0.63) | TAS1R3TAS1R1CA1CA2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |