Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 12/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195559 | 0.85 | PYGL (0.45) | PYGL | |
| SCHEMBL5194927 | 0.85 | PYGL (0.49) | PYGLCYP2C9 | |
| SCHEMBL5192086 | 0.85 | PYGL (0.49) | PYGLCYP2C9 | |
| SCHEMBL5195664 | 0.85 | ABCB1 (0.50) | PYGLCYP2C9 | |
| SCHEMBL5423348 | 0.85 | MMP13 (0.56) | PYGLCYP2C9 | |
| SCHEMBL5194286 | 0.83 | MMP13 (0.54) | PYGLCYP2C9 | |
| SCHEMBL5192561 | 0.80 | PYGL (0.71) | PYGLCYP2C9 | |
| SCHEMBL5193853 | 0.80 | PYGL (0.71) | PYGLCYP2C9 | |
| SCHEMBL5191862 | 0.78 | PYGL (0.55) | PYGLCYP2C9 | |
| SCHEMBL5195691 | 0.78 | PYGL (0.53) | PYGLCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |