Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA4 | P22748 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191931 | 0.78 | CA1 (0.34) | MMP3SMYD3CA1CA2CA4 | |
| Hydroxyamine SCHEMBL5894189 | 0.77 | FKBP1A (0.40) | MMP8MMP3FKBP1AALDH1A1MAPT | |
| SCHEMBL5192806 | 0.75 | GAA (0.33) | MMP3ALDH1A1CA1CA2CA4 | |
| SCHEMBL2919209 | 0.69 | TSHR (0.36) | MAPTCA1CA2CA4CA9 | |
| SCHEMBL5193793 | 0.68 | GBA2 (0.39) | ALDH1A1MAPTBCHECA1CA2 | |
| SCHEMBL27864833 | 0.67 | SMYD3 (0.36) | SMYD3CA1CA2CA4CA9 | |
| SCHEMBL25420992 | 0.67 | GNAO1 (0.43) | ALDH1A1MAPTGNAI3GNAO1GNAI1 | |
| SCHEMBL25253971 | 0.67 | GNAO1 (0.43) | ALDH1A1MAPTGNAI3GNAO1GNAI1 | |
| SCHEMBL10464788 | 0.67 | GNAO1 (0.43) | ALDH1A1MAPTGNAI3GNAO1GNAI1 | |
| SCHEMBL25420232 | 0.67 | GNAO1 (0.43) | ALDH1A1MAPTGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |