Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 14/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193891 | 0.92 | PYGL (0.52) | PYGLMEN1LMNAMAPTKMT2A | |
| SCHEMBL5418878 | 0.90 | PYGL (0.45) | PYGLMEN1LMNAMAPTKMT2A | |
| SCHEMBL5197711 | 0.89 | MEN1 (0.51) | PYGLMEN1LMNAMAPTKMT2A | |
| SCHEMBL5193196 | 0.88 | PYGL (0.55) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5193186 | 0.88 | PYGL (0.55) | PYGLCYP2C9CNR1CNR2 | |
| SCHEMBL5196793 | 0.87 | PYGL (0.53) | PYGLCYP2C9 | |
| SCHEMBL5196786 | 0.87 | PYGL (0.53) | PYGLCYP2C9 | |
| SCHEMBL5195223 | 0.85 | ABCB1 (0.47) | PYGLKMT2AABCB1 | |
| SCHEMBL5196528 | 0.84 | MMP13 (0.55) | PYGLMEN1LMNAMAPTKMT2A | |
| SCHEMBL5192583 | 0.83 | MMP13 (0.53) | MEN1LMNAMAPTKMT2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |