SCHEMBL5196294

SCHEMBL5196294

CC(C)(C)C(C[C@@H](CBr)NC(=O)OCc1ccccc1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.53
CTRB1 P17538 2/20 0.52
CTSK P43235 6/20 0.47
CTSS P25774 5/20 0.46
CTSL P07711 4/20 0.46
CTSB P07858 3/20 0.46
ELANE P08246 2/20 0.46
ATM Q13315 2/20 0.46
PRTN3 P24158 1/20 0.44
ITGB3 P05106 1/20 0.43
ITGA2B P08514 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL143122 0.90 SYK (0.53) SYKCTRB1CTSKCTSSCTSL
SCHEMBL16146358 0.90 SYK (0.53) SYKCTRB1CTSKCTSSCTSL
SCHEMBL143177 0.87 SYK (0.50) SYKCTRB1CTSKCTSSCTSL
SCHEMBL142589 0.86 SYK (0.49) SYKCTRB1CTSKCTSSCTSL
SCHEMBL27857330 0.85 CTSK (0.55) CTSKCTSSCTSLCTSBITGB3
SCHEMBL42878 0.85 CTSK (0.55) CTSKCTSSCTSLCTSBITGB3
SCHEMBL2776839 0.85 CTSK (0.55) CTSKCTSSCTSLCTSBITGB3
SCHEMBL29631961 0.81 CTSK (0.52) CTSKCTSSCTSLCTSBITGB3
SCHEMBL142267 0.81 CTSB (0.50) SYKCTRB1CTSKCTSSCTSL
SCHEMBL144788 0.81 SYK (0.45) SYKCTRB1CTSKCTSSCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1340756-B1 NOVEL BETA-LACTAM COMPOUNDS AND PROCESS FOR PRODUCING THE SAME DAINIPPON SUMITOMO PHARMA CO (JP) 2007-10-10 EP disclosed
US-7163936-B2 β-lactam compounds and process for producing the same DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-01-16 US disclosed
US-20040102433-A1 Novel beta-lactam compounds and process for producing the same DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2004-05-27 US disclosed
EP-1340756-A1 NOVEL BETA-LACTAM COMPOUNDS AND PROECSS FOR PRODUCING THE SAME SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102433-A1 Novel beta-lactam compounds and process for producing the same MRPL21, MCRS1, RPS4X SYK 2797/4885CTRB1 941/4885CTSK 2383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.