⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432069 | 0.83 | ADAM17 (0.33) | — | |
| SCHEMBL31257316 | 0.79 | KMT2A (0.33) | — | |
| SCHEMBL13446712 | 0.77 | ALDH1A1 (0.35) | — | |
| SCHEMBL12311377 | 0.74 | — | — | |
| SCHEMBL364115 | 0.74 | — | — | |
| SCHEMBL11829302 | 0.74 | — | — | |
| SCHEMBL12311378 | 0.74 | — | — | |
| SCHEMBL8709678 | 0.72 | — | — | |
| SCHEMBL20118159 | 0.72 | THRB (0.36) | — | |
| SCHEMBL25304619 | 0.71 | SLC6A2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117897378-A | Plants with increased tolerance to herbicides | 巴斯夫农业种子解决方案美国有限责任公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117794919-A | N- (hydroxyalkyl (hetero) aryl) tetrahydrofurancarboxamide analogues as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116710450-A | Pyrrolo [3,2-b ] pyridine derivatives for the treatment of cGAS-related disorders | 诺华股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-116635382-A | Indole derivatives useful for treating cGAS-related disorders | 诺华股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-115244035-A | Herbicidal phenyluracils | 巴斯夫欧洲公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-108558871-B | Tricyclic compounds as anticancer agents | 百时美施贵宝公司 | 2022-02-18 | — | — | CN | disclosed |
| EP-3643308-B1 | COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF | CSTONE PHARMACEUTICALS (KY) | 2021-05-19 | — | — | EP | disclosed |
| EP-3643308-A1 | COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF | CSTONE PHARMACEUTICALS (KY) | 2020-04-29 | — | — | EP | disclosed |
| CN-104710385-B | PDE10 inhibitor and compositions related and method | 奥默罗斯公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-102105149-A | Substituted carbamate derivatives as modulators of corticotropin-releasing factor receptor activity | BRISTOL MYERS SQUIBB CO | 2011-06-22 | — | — | CN | disclosed |
| US-20070281919-A1 | Aminothiazole Derivatives And Their Use As CRF Receptor Ligands | SANOFI-AVENTIS (FR) | 2007-12-06 | — | — | US | disclosed |
| CN-1953972-A | 1-amino-phthalazine derivatives, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2007-04-25 | — | — | CN | disclosed |
| EP-1737840-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005103033-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-11-03 | — | — | WO | disclosed |
| CN-1167692-C | Aminothiazole derivatives and their use as CRF receptor ligands | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-09-22 | — | — | CN | disclosed |
| US-6586456-B1 | Corticotropin releasing factor (CRF) antagonists such as (4-(2-chloro-4-methoxy-5-methylphenyl)-5-methylthiazol-2-yl)(( (1-(3-fluoro-4-methylphenyl)-2-methoxyethyl))prop-2-ynylamine, prepared by alkylation with propagyl bromide | SANOFI-SYNTHELABO (FR) | 2003-07-01 | — | — | US | disclosed |
| CN-1370154-A | Aminothiazole derivatives and their use as CRF receptor ligands | SANOFI SYNTHELABO (FR) | 2002-09-18 | — | — | CN | disclosed |
| EP-1200419-A1 | AMINOTHIAZOLE DERIVATIVES AND THEIR USE AS CRF RECEPTOR LIGANDS | SANOFI-SYNTHELABO (FR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005776-A1 | AMINOTHIAZOLE DERIVATIVES AND THEIR USE AS CRF RECEPTOR LIGANDS | SANOFI-SYNTHELABO (FR) | 2001-01-25 | — | — | WO | disclosed |