Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 9/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195387 | 0.83 | ICMT (0.40) | ICMTPTK2ALDH1A1HSD17B10 | |
| SCHEMBL5097075 | 0.82 | CHRM3 (0.40) | CHRM1CHRM3HTR2CUSP2ALDH1A1 | |
| SCHEMBL5091011 | 0.76 | HTR1A (0.39) | GNAI3HTR2CUSP2ALDH1A1CYP1A2 | |
| SCHEMBL5090967 | 0.75 | HTR2C (0.42) | GNAI3FLT4HTR2CALDH1A1 | |
| SCHEMBL5097281 | 0.74 | OPRD1 (0.44) | CYP1A2CYP2D6 | |
| SCHEMBL5097001 | 0.74 | MKNK1 (0.41) | HTR2CCYP1A2HSD17B10CLK4 | |
| SCHEMBL4522720 | 0.71 | MAPT (0.35) | PTK2ALDH1A1 | |
| SCHEMBL5097024 | 0.70 | CHRM1 (0.39) | CHRM1CHRM3 | |
| SCHEMBL5505695 | 0.70 | CHRM1 (0.39) | ICMTCHRM1CHRM3HTR2C | |
| SCHEMBL5094846 | 0.68 | CHRM1 (0.42) | CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836196-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069275-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |