Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195687 | 0.89 | CYP1A2 (0.47) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL5196165 | 0.84 | MAPT (0.45) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL5193285 | 0.83 | POLB (0.51) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL5196161 | 0.80 | RAB9A (0.46) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL5193749 | 0.76 | CYP3A4 (0.50) | NPC1RAB9ATRPM8KDM4EALDH1A1 | |
| SCHEMBL5195341 | 0.76 | CYP1A2 (0.44) | NPC1RAB9ATRPM8ALOX5KDM4E | |
| SCHEMBL3809712 | 0.75 | POLB (0.50) | POLBNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL5196998 | 0.73 | CYP1A2 (0.48) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL5193874 | 0.70 | CYP1A2 (0.43) | POLBNPC1RAB9AL3MBTL1TRPM8 | |
| SCHEMBL13685249 | 0.70 | SMN1; SMN2 (0.61) | NPC1RAB9AL3MBTL1TRPM8ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1321463-B1 | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC (CA) | 2007-08-08 | — | — | EP | claimed |