Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182850 | 0.90 | ACKR3 (0.38) | S1PR1ACKR3GPR119TBK1KLKB1 | |
| SCHEMBL5172129 | 0.89 | ADRB3 (0.31) | ACKR3TBK1 | |
| SCHEMBL5197772 | 0.87 | S1PR1 (0.39) | S1PR1ACKR3TBK1S1PR4S1PR5 | |
| SCHEMBL5163138 | 0.82 | HRH3 (0.40) | S1PR1ACKR3GPR119 | |
| SCHEMBL5169161 | 0.79 | PRMT5 (0.36) | GPR119 | |
| SCHEMBL5171673 | 0.79 | PANK3 (0.37) | GPR119 | |
| SCHEMBL5662475 | 0.79 | GPR119 (0.48) | S1PR1GPR119TBK1IKBKE | |
| SCHEMBL5170763 | 0.78 | XIAP (0.32) | — | |
| SCHEMBL5170520 | 0.78 | KCNH2 (0.34) | — | |
| SCHEMBL5183239 | 0.77 | GRM2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |