Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PTBP1 | P26599 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197836 | 1.00 | MAOB (0.37) | MAOBNPSR1SMN1; SMN2MAPTLSS | |
| SCHEMBL5199112 | 0.85 | NPSR1 (0.43) | MAOBNPSR1SMN1; SMN2MAPTLSS | |
| SCHEMBL5197704 | 0.77 | KMT2A (0.48) | NPSR1MAPTMEN1KMT2A | |
| SCHEMBL5197710 | 0.77 | KMT2A (0.48) | NPSR1MAPTMEN1KMT2A | |
| SCHEMBL5199263 | 0.74 | NPC1 (0.37) | NPSR1SMN1; SMN2MAPTMGAMGAA | |
| SCHEMBL5199254 | 0.74 | NPC1 (0.37) | NPSR1SMN1; SMN2MAPTMGAMGAA | |
| SCHEMBL5196158 | 0.74 | LSS (0.34) | NPSR1LSSMAPK11MAPK14MAPK1 | |
| SCHEMBL5194034 | 0.73 | TEK (0.42) | NPSR1LMNAEGFRIDO1PSD | |
| SCHEMBL5200281 | 0.72 | LSS (0.33) | NPSR1LSSMAPK11MAPK14MAPK1 | |
| SCHEMBL5196925 | 0.72 | MAPK14 (0.49) | IDO1MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |