Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 5/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | PRKX | P51817 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196158 | 0.93 | LSS (0.34) | LSSCNR1MAPK14MAPK11MAPK13 | |
| SCHEMBL5199937 | 0.85 | MAPK14 (0.42) | LSSCNR1MAPK14MAPK11MAPK13 | |
| SCHEMBL5330737 | 0.83 | CNR1 (0.39) | LSSCNR1MAPK14MAPK11MAPK13 | |
| SCHEMBL5197704 | 0.80 | KMT2A (0.48) | ALDH1A1NPSR1TEK | |
| SCHEMBL5197710 | 0.80 | KMT2A (0.48) | ALDH1A1NPSR1TEK | |
| SCHEMBL5199263 | 0.77 | NPC1 (0.37) | MAPK14MAPK11MAPK13MAPK12BRAF | |
| SCHEMBL5199254 | 0.77 | NPC1 (0.37) | MAPK14MAPK11MAPK13MAPK12BRAF | |
| SCHEMBL5200392 | 0.76 | MAPK14 (0.41) | LSSMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5198449 | 0.74 | AAK1 (0.42) | LSSCNR1MAPK14MAPK11MAPK13 | |
| SCHEMBL5197840 | 0.72 | MAOB (0.37) | LSSMAPK14MAPK11MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |